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Vector Laboratories dab kit
Dab Kit, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Danaher Inc anti lamp1 polyclonal antibody
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
Anti Lamp1 Polyclonal Antibody, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Vector Laboratories dab substrate
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
Dab Substrate, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Boster Bio boster biological technology ar1022
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
Boster Biological Technology Ar1022, supplied by Boster Bio, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Boster Bio dab chromogenic substrate kit
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
Dab Chromogenic Substrate Kit, supplied by Boster Bio, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Beijing Solarbio Science 20× metal enhanced dab substrate kit
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
20× Metal Enhanced Dab Substrate Kit, supplied by Beijing Solarbio Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ScyTek Inc dab chromogen/substrate kit (high contrast)
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
Dab Chromogen/Substrate Kit (High Contrast), supplied by ScyTek Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Linaris GmbH dab substrate kit
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
Dab Substrate Kit, supplied by Linaris GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Diagnostic BioSystems stable dab plus chromogen
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
Stable Dab Plus Chromogen, supplied by Diagnostic BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ZSGB Biotech peroxidase substrate kit dab
Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse <t>anti-LAMP1</t> antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.
Peroxidase Substrate Kit Dab, supplied by ZSGB Biotech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse anti-LAMP1 antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.

Journal: Scientific Reports

Article Title: CRISPR-mediated generation and characterization of a Gaa homozygous c.1935C>A (p.D645E) Pompe disease knock-in mouse model recapitulating human infantile onset-Pompe disease

doi: 10.1038/s41598-022-25914-8

Figure Lengend Snippet: Tissue pathology in Gaa em1935C > A KI mice showing glycogen storage in muscles and lysosomal abnormality in brains. ( A ) Representative bright-field images of heart, diaphragm, and gastrocnemius sections from 3-month-old WT and KI mice, stained with hematoxylin/PAS. Areas of abnormal glycogen accumulation (arrowheads) in cardiac and skeletal muscle tissues were observed in KI mice compared to WT mice (top). ( B ) Immunohistostaining with mouse anti-LAMP1 antibody showing increased cell body staining (arrowheads) in frontal and hippocampal neurons and Purkinje cells of KI mice from all three representative brain areas (frontal cortex, hippocampus and cerebellum). Scale bar represents 100 µm.

Article Snippet: LAMP1 immunohistochemistry staining in paraffin-embedded brain sections from study animals were performed with anti-LAMP1 polyclonal antibody (Cat#24170, Abcam, Waltham, MA) using an ImmPACT DAB Substrate Kit with Peroxidase (Vector Laboratories, Burlingame, CA) following manufacturer’s instructions.

Techniques: Muscles, Staining